Endocrine Abstracts

Introduction: Medullary thyroid carcinoma (MTC) is a rare neoplasm that occurs sporadically in 75% (sMTC) and hereditarily in 25% (fMTC) of cases caused by germinal mutations of the RET gene as an autosomal dominant trait. fMTC occurs in the setting of three syndromes: fMTC alone without any other clinical manifestations; and multiple endocrine neoplasia type 2A (MEN2A) and 2B (MEN2B) syndromes. In fMTC, cases are distinguished into index cases (1st clinically detecte...